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Publications

20. Imbalanced chromatin distribution in cellular senescence specifies paraspeckle dynamics. JL Lee, JM Choi, JE Park, SD Lee, E Cho, Y Gwon. Genome Biology (2025) 26(1):264.

19. Suppression of stress granule assembly by pyridoxal hydrochloride attenuates oxidative damage in skin fibroblasts. SH Kim, YH Kim, JB Kim, NY Park, JH So, D Park, DK Choi, E Yeom, Y Gwon, DS Jo, JA Lee, JE Bae, DH Cho. Bioorganic & Medicinal Chemistry Letters (2025) 123, 130238.

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18. Low-dose rapamycin microdepots promote hair regrowth via autophagy modulation. TT Nguyen, TNH Le, NN Nguyen, S Yook, D Ryu, G Orive, Y Gwon, JH Sung, JH Jeong. Journal of Pharmaceutical Investigation (2025),  1-10.

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17. Catechol-modified stabilizer facilitates impulsive ligand functionalization of particulates and membrane modification of cells. P Shrestha, S Pathak, S Regmi, YS Youn, JH Jeong, JH Lee, D Ryu, S Yook, Y Gwon, JU Choi, HL Jiang, JY Kim, JH Jeong. Journal of Drug Delivery Science and Technology (2024) 101, 106161.

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16. Reduced dynamicity and increased high-order protein assemblies in dense fibrillar component of the nucleolus under cellular senescence. M Jo, S Kim, J Park, YT Chang, Y Gwon. Redox Biology (2024) 75, 103279.

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15. Strengthened binding affinity of bispecific antibody nanoplatforms improved the anti-tumor efficacy. R Duwa, J Choi, P Shrestha, TTK Nguyen, LD Bastatas, Y Gwon, S Park, JH Jeong, S Yook. Chemical Engineering Journal (2024) 494, 153128.

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14. Endolysosomal impairment by binding of amyloid beta or MAPT/Tau to V-ATPase and rescue via the HYAL-CD44 axis in Alzheimer disease. SH Kim, YS Cho, Y Kim, J Park, SM Yoo, J Gwak, Y Kim, Y Gwon, T Kam, YK Jung. Autophagy (2023) 19 (8), 2318-2337.

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13. Neuronal biomolecular condensates and their implications in neurodegenerative diseases. J Nam, Y Gwon. Frontiers in Aging Neuroscience (2023) 15, 1145420.

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12. Aberrant role of ALK in tau proteinopathy through autophagosomal dysregulation. J Park, H Choi, YD Kim, SH Kim, Y Kim, Y Gwon, DY Lee, SH Park, WD Heo, WK jung. Molecular Psychiatry (2021) 26 (10), 5542-5556.

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11. Ubiquitination is essential for recovery of cellular activities after heat shock. BA Maxwell, Y Gwon, A Mishra, J Peng, H Nakamura, K Zhang, HJ Kim, JP Taylor. Science (2021) 372 (6549), eabc3593.

10. Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner. Y Gwon, BA Maxwell, RM Kolaitis, P Zhang, HJ Kim, JP Taylor. Science (2021) 372(6549), eabf6548.

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9. SERP1 is an assembly regulator of γ-secretase in metabolic stress conditions. S Jung, J Hyun, J Nah, J Han, SH Kim, J Park, Y Oh, Y Gwon, S Moon, DG Jo, YK Jung. Science signaling (2020) 13 (623), eaax8949.

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8. Cardioprotective role of APIP in myocardial infarction through ADORA2B. B Lim, K Jung, Y Gwon, JG Oh, J Roh, SH Hong, C Kho, WJ Park, HW Lee, JY Bae, YK Jung. Cell Death & Disease (2019) 10 (7), 511

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7. ULK1 and ULK2 regulate stress granule disassembly through phosphorylation and activation of VCP/p97. B Wang, BA Maxwell, JH Joo, Y Gwon, J Messing, A Mishra, TI Shaw, AL Ward, H Quan, SM Sakurada, SM Pruett-Miller, T Bertorini, P Vogel, HJ Kim, J Peng, JP Taylor, M Kundu. Molecular cell (2019) 74 (4), 742-757. e8


6. Amelioration of amyloid β-FcγRIIb neurotoxicity and tau pathologies by targeting LYN. Y Gwon, SH Kim, HT Kim, TI Kam, J Park, B Lim, H Cha, HJ Chang, YR Hong, YK Jung. The FASEB Journal (2019) 33(3), 4300-4313.

5. TOM1 regulates neuronal accumulation of amyloid-β oligomers by FcγRIIb2 variant in Alzheimers disease. Y Gwon*, TI Kam*, SH Kim, S Song, H Park, B Lim, H Lee, W Lee, DG Jo, YK Jung. Journal of Neuroscience (2018) 38(42), 9001-9018.&160(* equal contribution)

4. FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimers disease model. TI Kam*, H Park*, Y Gwon*, S Song, SH Kim, SW Moon, DG Jo, YK Jung. Elife (2016) 5, e18691. (* equal contribution)

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3. Amyloid beta receptors responsible for neurotoxicity and cellular defects in Alzheimer’s disease. TI Kam, Y Gwon, YK Jung. Cellular and molecular life sciences (2014) 71 (24), 4803-4813

2. FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer’s disease. TI Kam, S Song, Y Gwon, H Park, JJ Yan, I Im, JW Choi, TY Choi, J Kim, DK Song, T Takai, YC Kim, KS Kim, SY Choi, S Choi, WL Klein, J Yuan, YK Jung. The Journal of clinical investigation (2013) 123 (7), 2791-2802

1. Neuropathogenic role of adenylate kinase-1 in Aβ-mediated tau phosphorylation via AMPK and GSK3β. H Park, TI Kam, Y Kim, H Choi, Y Gwon, C Kim, JY Koh, YK Jung. Human molecular genetics (2012) 21 (12), 2725-2737

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Laboratory of Cellular Stress, Aging, and Human diseases

​16419 경기도 수원시 장안구 서부로 2066 성균관대학교 의과대학 

Sungkyunkwan University, School of Medicine2066 Seobu-ro, Jangan-gu, Suwon-si, Gyeonggi-do, 16419, Republic of Korea

TEL : 82-31-299-6164

Email : ygwon@skku.edu

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